Human Coronaviruses Associated with Upper Respiratory Tract Infections in Three Rural Areas of Ghana
Identifieur interne : 001C36 ( Main/Exploration ); précédent : 001C35; suivant : 001C37Human Coronaviruses Associated with Upper Respiratory Tract Infections in Three Rural Areas of Ghana
Auteurs : Michael Owusu [Ghana] ; Augustina Annan [Ghana] ; Victor Max Corman [Allemagne] ; Richard Larbi [Ghana] ; Priscilla Anti [Ghana] ; Jan Felix Drexler [Allemagne] ; Olivia Agbenyega [Ghana] ; Yaw Adu-Sarkodie [Ghana] ; Christian Drosten [Allemagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Coronavirus humain NL63 (génétique), Femelle, Ghana (épidémiologie), Humains, Infections de l'appareil respiratoire (virologie), Infections de l'appareil respiratoire (épidémiologie), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Jeune adulte, Mâle, RT-PCR, Saisons, Techniques de diagnostic moléculaire, Études cas-témoins.
- MESH :
- génétique : Coronavirus humain NL63.
- virologie : Infections de l'appareil respiratoire, Infections à coronavirus.
- épidémiologie : Ghana, Infections de l'appareil respiratoire, Infections à coronavirus.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, RT-PCR, Saisons, Techniques de diagnostic moléculaire, Études cas-témoins.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- Adult, Case-Control Studies, Coronavirus Infections (epidemiology), Coronavirus Infections (virology), Coronavirus NL63, Human (genetics), Female, Ghana (epidemiology), Humans, Male, Middle Aged, Molecular Diagnostic Techniques, Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (virology), Reverse Transcriptase Polymerase Chain Reaction, Seasons, Young Adult.
- MESH :
- geographic , epidemiology : Ghana.
- epidemiology : Coronavirus Infections, Respiratory Tract Infections.
- genetics : Coronavirus NL63, Human.
- virology : Coronavirus Infections, Respiratory Tract Infections.
- Adult, Case-Control Studies, Female, Humans, Male, Middle Aged, Molecular Diagnostic Techniques, Reverse Transcriptase Polymerase Chain Reaction, Seasons, Young Adult.
Abstract
Acute respiratory tract infections (ARI) are the leading cause of morbidity and mortality in developing countries, especially in Africa. This study sought to determine whether human coronaviruses (HCoVs) are associated with upper respiratory tract infections among older children and adults in Ghana.
We conducted a case control study among older children and adults in three rural areas of Ghana using asymptomatic subjects as controls. Nasal/Nasopharyngeal swabs were tested for Middle East respiratory syndrome coronavirus (MERS-CoV), HCoV-22E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 using Reverse Transcriptase Real-Time Polymerase Chain Reaction.
Out of 1,213 subjects recruited, 150 (12.4%) were positive for one or more viruses. Of these, single virus detections occurred in 146 subjects (12.0%) and multiple detections occurred in 4 (0.3%). Compared with control subjects, infections with HCoV-229E (OR = 5.15, 95%CI = 2.24–11.78), HCoV-OC43 (OR = 6.16, 95%CI = 1.77–21.65) and combine HCoVs (OR = 2.36, 95%CI = 1.5 = 3.72) were associated with upper respiratory tract infections. HCoVs were found to be seasonally dependent with significant detections in the harmattan season (mainly HCoV-229E) and wet season (mainly HCoV-NL63). A comparison of the obtained sequences resulted in no differences to sequences already published in GenBank.
HCoVs could play significant role in causing upper respiratory tract infections among adults and older children in rural areas of Ghana.
Url:
DOI: 10.1371/journal.pone.0099782
PubMed: 25080241
PubMed Central: 4117488
Affiliations:
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Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Annan, Augustina" sort="Annan, Augustina" uniqKey="Annan A" first="Augustina" last="Annan">Augustina Annan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Corman, Victor Max" sort="Corman, Victor Max" uniqKey="Corman V" first="Victor Max" last="Corman">Victor Max Corman</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Bonn Medical Centre, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Larbi, Richard" sort="Larbi, Richard" uniqKey="Larbi R" first="Richard" last="Larbi">Richard Larbi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Anti, Priscilla" sort="Anti, Priscilla" uniqKey="Anti P" first="Priscilla" last="Anti">Priscilla Anti</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Institute of Renewable and Natural Resources, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Institute of Renewable and Natural Resources, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Drexler, Jan Felix" sort="Drexler, Jan Felix" uniqKey="Drexler J" first="Jan Felix" last="Drexler">Jan Felix Drexler</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Bonn Medical Centre, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Agbenyega, Olivia" sort="Agbenyega, Olivia" uniqKey="Agbenyega O" first="Olivia" last="Agbenyega">Olivia Agbenyega</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Institute of Renewable and Natural Resources, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Institute of Renewable and Natural Resources, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Adu Sarkodie, Yaw" sort="Adu Sarkodie, Yaw" uniqKey="Adu Sarkodie Y" first="Yaw" last="Adu-Sarkodie">Yaw Adu-Sarkodie</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line></nlm:aff><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Institute of Virology, University of Bonn Medical Centre, Bonn, Germany</addr-line></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, University of Bonn Medical Centre, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Case-Control Studies</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (virology)</term><term>Coronavirus NL63, Human (genetics)</term><term>Female</term><term>Ghana (epidemiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Diagnostic Techniques</term><term>Respiratory Tract Infections (epidemiology)</term><term>Respiratory Tract Infections (virology)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Seasons</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Coronavirus humain NL63 (génétique)</term><term>Femelle</term><term>Ghana (épidémiologie)</term><term>Humains</term><term>Infections de l'appareil respiratoire (virologie)</term><term>Infections de l'appareil respiratoire (épidémiologie)</term><term>Infections à coronavirus (virologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Jeune adulte</term><term>Mâle</term><term>RT-PCR</term><term>Saisons</term><term>Techniques de diagnostic moléculaire</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus NL63, Human</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus humain NL63</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term><term>Infections de l'appareil respiratoire</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Diagnostic Techniques</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Seasons</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>RT-PCR</term><term>Saisons</term><term>Techniques de diagnostic moléculaire</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Acute respiratory tract infections (ARI) are the leading cause of morbidity and mortality in developing countries, especially in Africa. This study sought to determine whether human coronaviruses (HCoVs) are associated with upper respiratory tract infections among older children and adults in Ghana.</p></sec><sec><title>Methods</title><p>We conducted a case control study among older children and adults in three rural areas of Ghana using asymptomatic subjects as controls. Nasal/Nasopharyngeal swabs were tested for Middle East respiratory syndrome coronavirus (MERS-CoV), HCoV-22E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 using Reverse Transcriptase Real-Time Polymerase Chain Reaction.</p></sec><sec><title>Results</title><p>Out of 1,213 subjects recruited, 150 (12.4%) were positive for one or more viruses. Of these, single virus detections occurred in 146 subjects (12.0%) and multiple detections occurred in 4 (0.3%). Compared with control subjects, infections with HCoV-229E (OR = 5.15, 95%CI = 2.24–11.78), HCoV-OC43 (OR = 6.16, 95%CI = 1.77–21.65) and combine HCoVs (OR = 2.36, 95%CI = 1.5 = 3.72) were associated with upper respiratory tract infections. HCoVs were found to be seasonally dependent with significant detections in the harmattan season (mainly HCoV-229E) and wet season (mainly HCoV-NL63). A comparison of the obtained sequences resulted in no differences to sequences already published in GenBank.</p></sec><sec><title>Conclusion</title><p>HCoVs could play significant role in causing upper respiratory tract infections among adults and older children in rural areas of Ghana.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Denny, Fw" uniqKey="Denny F">FW Denny</name></author><author><name sortKey="Loda, Fa" uniqKey="Loda F">FA Loda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, Bg" uniqKey="Williams B">BG Williams</name></author><author><name sortKey="Gouws, E" uniqKey="Gouws E">E Gouws</name></author><author><name sortKey="Boschi Pinto, C" uniqKey="Boschi Pinto C">C Boschi-Pinto</name></author><author><name sortKey="Bryce, J" uniqKey="Bryce J">J Bryce</name></author><author><name sortKey="Dye, C" uniqKey="Dye C">C 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sortKey="Grant, Wb" uniqKey="Grant W">WB Grant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaman, J" uniqKey="Shaman J">J Shaman</name></author><author><name sortKey="Kohn, M" uniqKey="Kohn M">M Kohn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adefolalu, Do" uniqKey="Adefolalu D">DO Adefolalu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niang, M" uniqKey="Niang M">M Niang</name></author><author><name sortKey="Diop, O" uniqKey="Diop O">O Diop</name></author><author><name sortKey="Sarr, F" uniqKey="Sarr F">F Sarr</name></author><author><name sortKey="Goudiaby, D" uniqKey="Goudiaby D">D Goudiaby</name></author><author><name sortKey="Malou Sompy, H" uniqKey="Malou Sompy H">H Malou-Sompy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dominguez, Sr" uniqKey="Dominguez S">SR Dominguez</name></author><author><name sortKey="Sims, Ge" uniqKey="Sims G">GE Sims</name></author><author><name sortKey="Wentworth, De" uniqKey="Wentworth D">DE Wentworth</name></author><author><name sortKey="Halpin, Ra" uniqKey="Halpin R">RA Halpin</name></author><author><name sortKey="Robinson, Cc" uniqKey="Robinson C">CC Robinson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Ghana</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Bonn</li></settlement></list><tree><country name="Ghana"><noRegion><name sortKey="Owusu, Michael" sort="Owusu, Michael" uniqKey="Owusu M" first="Michael" last="Owusu">Michael Owusu</name></noRegion><name sortKey="Adu Sarkodie, Yaw" sort="Adu Sarkodie, Yaw" uniqKey="Adu Sarkodie Y" first="Yaw" last="Adu-Sarkodie">Yaw Adu-Sarkodie</name><name sortKey="Agbenyega, Olivia" sort="Agbenyega, Olivia" uniqKey="Agbenyega O" first="Olivia" last="Agbenyega">Olivia Agbenyega</name><name sortKey="Annan, Augustina" sort="Annan, Augustina" uniqKey="Annan A" first="Augustina" last="Annan">Augustina Annan</name><name sortKey="Anti, Priscilla" sort="Anti, Priscilla" uniqKey="Anti P" first="Priscilla" last="Anti">Priscilla Anti</name><name sortKey="Larbi, Richard" sort="Larbi, Richard" uniqKey="Larbi R" first="Richard" last="Larbi">Richard Larbi</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Corman, Victor Max" sort="Corman, Victor Max" uniqKey="Corman V" first="Victor Max" last="Corman">Victor Max Corman</name></region><name sortKey="Drexler, Jan Felix" sort="Drexler, Jan Felix" uniqKey="Drexler J" first="Jan Felix" last="Drexler">Jan Felix Drexler</name><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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